A 15-year study of 132,000 people suggests that early statin use may lower the risk of developing dementia by up to 15%.

A study tracking over 132,000 people in Denmark between 2006 and 2021 suggests that statins may help reduce the risk of dementia. Presented at the European Society of Cardiology congress, the research indicates that starting statin treatment earlier in life is associated with a greater reduction in risk compared to later initiation. The findings were simultaneously published in the journal Lancet Regional Health Europe.

Study Findings and Methodology

The observational study focused on individuals with type 2 diabetes. Researchers found that participants who began taking statins early in the study period saw a 15% lower relative risk of developing dementia over 10 years, while those who started later saw a 10% reduction. Among the total cohort of 132,585 people, 2.7% developed dementia during the 15-year follow-up.

Potential Biological Mechanisms

Statins are known to lower low-density lipoprotein (LDL) cholesterol, which can prevent plaque buildup in arteries. Experts suggest that high LDL cholesterol may contribute to dementia by hardening or narrowing the blood vessels that supply the brain. By protecting against atherosclerosis and related cardiovascular issues, statins may help maintain blood flow and prevent damage to brain tissue.

Expert Perspective

While the findings are considered plausible, researchers noted that as an observational study, it demonstrates an association rather than proving a direct causal link. Dr. Honorine Lebraud of Alzheimer’s Research UK stated that further work is required to confirm the connection, though the study adds to existing evidence that cardiovascular health is closely linked to brain health.